Rifampin FDA Link Generic

A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)

Also Known As:

Rifampicin; Benemycin; Rifadin; Rimactan; Rimactane; Tubocin; Rifamycin, 3- (((4- methyl- 1- piperazinyl)imino)methyl)-

Pharmalogical Action Categories:

Antibiotics, Antitubercular
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 CYP2C19 Inducers
Cytochrome P-450 CYP2C8 Inducers
Cytochrome P-450 CYP2C9 Inducers
Cytochrome P-450 CYP3A Inducers
Leprostatic Agents
Nucleic Acid Synthesis Inhibitors

Heterocyclic Compounds: 207
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - Rifamycins: 422
      - Rifampin: 9028
Polycyclic Compounds: 7
- Macrocyclic Compounds: 16
  - Macrocyclic Lactams: 28
    - Rifamycins: 422
      - Rifampin: 9028

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